Dr. House exasperates his boss, Dr. Lisa Cuddy, when he suggests that two sick newborn babies in one hospital add up to an epidemic. Even more frightening is the fact he may be right. As more babies are quarantined and the maternity ward is shut down, Cuddy power-scrubs the hospital and House spars with Dr. Cameron and his team of specialists over his plan to possibly sacrifice one sick baby for the good of the others.